Gene expression and epigenetic discovery screen reveal methylation of SFRP2 in prostate cancer

Aberrant activation of Wnts is common in human cancers, including prostate. Hypermethylation associated transcriptional silencing of Wnt antagonist genes SFRPs (Secreted Frizzled-Related Proteins) is a frequent oncogenic event. The significance of this is not known in prostate cancer. The objectives...

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Détails bibliographiques
Publié dans:Int J Cancer
Auteurs principaux: Perry, Antoinette S., O’Hurley, Gillian, Raheem, Omer A., Brennan, Kevin, Wong, Simon, O’Grady, Anthony, Kennedy, Anne-Marie, Marignol, Laure, Murphy, Therese M., Sullivan, Linda, Barrett, Ciara, Loftus, Barbara, Thornhill, John, Hewitt, Stephen M., Lawler, Mark, Kay, Elaine, Lynch, Thomas, Hollywood, Donal
Format: Artigo
Langue:Inglês
Publié: 2012
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7560947/
https://ncbi.nlm.nih.gov/pubmed/22915211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.27798
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