Homozygous Smpd1 deficiency aggravates brain ischemia/ reperfusion injury by mechanisms involving polymorphonuclear neutrophils, whereas heterozygous Smpd1 deficiency protects against mild focal cerebral ischemia

By cleaving sphingomyelin into ceramide, which is an essential component of plasma membrane microdomains, acid sphingomyelinase (Asm) pivotally controls cell signaling. To define how the activation of the Asm/ceramide pathway, which occurs within seconds to minutes upon stress stimuli, influences br...

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Bibliografske podrobnosti
izdano v:Basic Res Cardiol
Main Authors: Hagemann, Nina, Mohamud Yusuf, Ayan, Martiny, Carlotta, Zhang, Xiaoni, Kleinschnitz, Christoph, Gunzer, Matthias, Kolesnick, Richard, Gulbins, Erich, Hermann, Dirk M.
Format: Artigo
Jezik:Inglês
Izdano: Springer Berlin Heidelberg 2020
Teme:
Original Contribution
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7560939/
https://ncbi.nlm.nih.gov/pubmed/33057972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00395-020-00823-x
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