Homozygous Smpd1 deficiency aggravates brain ischemia/ reperfusion injury by mechanisms involving polymorphonuclear neutrophils, whereas heterozygous Smpd1 deficiency protects against mild focal cerebral ischemia

By cleaving sphingomyelin into ceramide, which is an essential component of plasma membrane microdomains, acid sphingomyelinase (Asm) pivotally controls cell signaling. To define how the activation of the Asm/ceramide pathway, which occurs within seconds to minutes upon stress stimuli, influences br...

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Dettagli Bibliografici
Pubblicato in:Basic Res Cardiol
Autori principali: Hagemann, Nina, Mohamud Yusuf, Ayan, Martiny, Carlotta, Zhang, Xiaoni, Kleinschnitz, Christoph, Gunzer, Matthias, Kolesnick, Richard, Gulbins, Erich, Hermann, Dirk M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Berlin Heidelberg 2020
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Original Contribution
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7560939/
https://ncbi.nlm.nih.gov/pubmed/33057972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00395-020-00823-x
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