Evolution of DNA replication origin specification and gene silencing mechanisms

DNA replication in eukaryotic cells initiates from replication origins that bind the Origin Recognition Complex (ORC). Origin establishment requires well-defined DNA sequence motifs in Saccharomyces cerevisiae and some other budding yeasts, but most eukaryotes lack sequence-specific origins. A 3.9 Å...

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Udgivet i:Nat Commun
Main Authors: Hu, Y., Tareen, A., Sheu, Y-J., Ireland, W. T., Speck, C., Li, H., Joshua-Tor, L., Kinney, J. B., Stillman, B.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7560902/
https://ncbi.nlm.nih.gov/pubmed/33056978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18964-x
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