CRISPR screening of porcine sgRNA library identifies host factors associated with Japanese encephalitis virus replication

Japanese encephalitis virus (JEV) is a mosquito-borne zoonotic flavivirus that causes encephalitis and reproductive disorders in mammalian species. However, the host factors critical for its entry, replication, and assembly are poorly understood. Here, we design a porcine genome-scale CRISPR/Cas9 kn...

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Vydáno v:Nat Commun
Hlavní autoři: Zhao, Changzhi, Liu, Hailong, Xiao, Tianhe, Wang, Zichang, Nie, Xiongwei, Li, Xinyun, Qian, Ping, Qin, Liuxing, Han, Xiaosong, Zhang, Jinfu, Ruan, Jinxue, Zhu, Mengjin, Miao, Yi-Liang, Zuo, Bo, Yang, Kui, Xie, Shengsong, Zhao, Shuhong
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7560704/
https://ncbi.nlm.nih.gov/pubmed/33057066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18936-1
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