Ubiquitin ligase CHIP regulates OTUD3 stability and suppresses tumour metastasis in lung cancer

Ovarian tumour domain-containing protein 3 (OTUD3), a key OTU (ovarian tumour protease) family deubiquitylase, plays context-dependent roles in cancers. It suppresses tumorigenesis in breast, colon, liver and cervical cancer through stabilizing PTEN (phosphatase and tension homologue deleted on chro...

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Publicado en:Cell Death Differ
Autores principales: Zhang, Pengfei, Li, Chaonan, Li, Hongchang, Yuan, Lin, Dai, Hongmiao, Peng, Zhiqiang, Deng, Zhikang, Chang, Zhijie, Cui, Chun-Ping, Zhang, Lingqiang
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7560627/
https://ncbi.nlm.nih.gov/pubmed/32483383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-0571-7
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