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A metabolite binding protein moonlights as a bile‐responsive chaperone

Bile salts are secreted into the gastrointestinal tract to aid in the absorption of lipids. In addition, bile salts show potent antimicrobial activity in part by mediating bacterial protein unfolding and aggregation. Here, using a protein folding sensor, we made the surprising discovery that the Esc...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:EMBO J
Hauptverfasser: Lee, Changhan, Betschinger, Patrick, Wu, Kevin, Żyła, Dawid S, Glockshuber, Rudi, Bardwell, James CA
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7560199/
https://ncbi.nlm.nih.gov/pubmed/32882062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019104231
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