Ablation of polyamine catabolic enzymes provokes Purkinje cell damage, neuroinflammation, and severe ataxia

BACKGROUND: Polyamine catabolism plays a key role in maintaining intracellular polyamine pools, yet its physiological significance is largely unexplored. Here, we report that the disruption of polyamine catabolism leads to severe cerebellar damage and ataxia, demonstrating the fundamental role of po...

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Bibliografiske detaljer
Udgivet i:J Neuroinflammation
Main Authors: Zahedi, Kamyar, Brooks, Marybeth, Barone, Sharon, Rahmati, Negah, Murray Stewart, Tracy, Dunworth, Matthew, Destefano-Shields, Christina, Dasgupta, Nupur, Davidson, Steve, Lindquist, Diana M., Fuller, Christine E., Smith, Roger D., Cleveland, John L., Casero, Robert A., Soleimani, Manoocher
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2020
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7559641/
https://ncbi.nlm.nih.gov/pubmed/33054763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-020-01955-6
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