Ablation of polyamine catabolic enzymes provokes Purkinje cell damage, neuroinflammation, and severe ataxia

BACKGROUND: Polyamine catabolism plays a key role in maintaining intracellular polyamine pools, yet its physiological significance is largely unexplored. Here, we report that the disruption of polyamine catabolism leads to severe cerebellar damage and ataxia, demonstrating the fundamental role of po...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Neuroinflammation
Egile Nagusiak: Zahedi, Kamyar, Brooks, Marybeth, Barone, Sharon, Rahmati, Negah, Murray Stewart, Tracy, Dunworth, Matthew, Destefano-Shields, Christina, Dasgupta, Nupur, Davidson, Steve, Lindquist, Diana M., Fuller, Christine E., Smith, Roger D., Cleveland, John L., Casero, Robert A., Soleimani, Manoocher
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2020
Gaiak:
Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7559641/
https://ncbi.nlm.nih.gov/pubmed/33054763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-020-01955-6
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak