Ablation of polyamine catabolic enzymes provokes Purkinje cell damage, neuroinflammation, and severe ataxia

BACKGROUND: Polyamine catabolism plays a key role in maintaining intracellular polyamine pools, yet its physiological significance is largely unexplored. Here, we report that the disruption of polyamine catabolism leads to severe cerebellar damage and ataxia, demonstrating the fundamental role of po...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Zahedi, Kamyar, Brooks, Marybeth, Barone, Sharon, Rahmati, Negah, Murray Stewart, Tracy, Dunworth, Matthew, Destefano-Shields, Christina, Dasgupta, Nupur, Davidson, Steve, Lindquist, Diana M., Fuller, Christine E., Smith, Roger D., Cleveland, John L., Casero, Robert A., Soleimani, Manoocher
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7559641/
https://ncbi.nlm.nih.gov/pubmed/33054763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-020-01955-6
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