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Regulatory role of SphK1 in TLR7/9-dependent type I interferon response and autoimmunity
Plasmacytoid dendritic cells (pDCs) express Toll like receptors (TLRs) that modulate the immune response by production of type I interferons. Here, we report that sphingosine kinase 1 (SphK1) which produces the bioactive sphingolipid metabolite, sphingosine 1-phosphate (S1P), plays a critical role i...
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| Publicat a: | FASEB J |
|---|---|
| Autors principals: | , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7559288/ https://ncbi.nlm.nih.gov/pubmed/31971297 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201902847R |
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