Regulatory role of SphK1 in TLR7/9-dependent type I interferon response and autoimmunity

Plasmacytoid dendritic cells (pDCs) express Toll like receptors (TLRs) that modulate the immune response by production of type I interferons. Here, we report that sphingosine kinase 1 (SphK1) which produces the bioactive sphingolipid metabolite, sphingosine 1-phosphate (S1P), plays a critical role i...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:FASEB J
Autores principales: Mohammed, Sabira, Vineetha, Nalanda S., James, Shirley, Aparna, Jayasekharan S., Lankadasari, Manendra Babu, Maeda, Takahiro, Ghosh, Abhirupa, Saha, Sudipto, Li, Quan-Zhen, Spiegel, Sarah, Harikumar, Kuzhuvelil B.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7559288/
https://ncbi.nlm.nih.gov/pubmed/31971297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201902847R
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares