Regulatory role of SphK1 in TLR7/9-dependent type I interferon response and autoimmunity

Plasmacytoid dendritic cells (pDCs) express Toll like receptors (TLRs) that modulate the immune response by production of type I interferons. Here, we report that sphingosine kinase 1 (SphK1) which produces the bioactive sphingolipid metabolite, sphingosine 1-phosphate (S1P), plays a critical role i...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Mohammed, Sabira, Vineetha, Nalanda S., James, Shirley, Aparna, Jayasekharan S., Lankadasari, Manendra Babu, Maeda, Takahiro, Ghosh, Abhirupa, Saha, Sudipto, Li, Quan-Zhen, Spiegel, Sarah, Harikumar, Kuzhuvelil B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7559288/
https://ncbi.nlm.nih.gov/pubmed/31971297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201902847R
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