A Colon-Targeted Prodrug, 4-Phenylbutyric Acid-Glutamic Acid Conjugate, Ameliorates 2,4-Dinitrobenzenesulfonic Acid-Induced Colitis in Rats

An elevated level of endoplasmic reticulum (ER) stress is considered an aggravating factor for inflammatory bowel disease (IBD). To develop an ER-stress attenuator that is effective against colitis, 4-phenylbutyric acid (4-PBA), a chemical chaperone that alleviates ER stress, was conjugated with aci...

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Bibliographic Details
Published in:Pharmaceutics
Main Authors: Kim, Soojin, Lee, Seunghyun, Lee, Hanju, Ju, Sanghyun, Park, Sohee, Kwon, Doyoung, Yoo, Jin-Wook, Yoon, In-Soo, Min, Do Sik, Jung, Young-Suk, Jung, Yunjin
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7558321/
https://ncbi.nlm.nih.gov/pubmed/32899177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics12090843
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