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Instability of Amide Bond with Trifluoroacetic Acid (20%): Synthesis, Conformational Analysis, and Mechanistic Insights into Cleavable Amide Bond Comprising β-Troponylhydrazino Acid
[Image: see text] The instability of an amide bond with dilute trifluoroacetic acid (TFA) is a rare chemical event. The native amide bonds are stable even in the neat TFA, which is one of the reagents that releases the peptides from the solid support in the solid-supported peptide synthesis method....
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | ACS Omega |
|---|---|
| Prif Awduron: | , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
American Chemical Society
2020
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| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7557997/ https://ncbi.nlm.nih.gov/pubmed/33073142 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.0c03729 |
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