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TMPRSS2-ERG Fusion, a Common Genomic Alteration in Prostate Cancer Activates C-MYC and Abrogates Prostate Epithelial Differentiation

The high prevalence of TMPRSS2-ERG rearrangements (~60%) in prostate cancer (CaP) leads to androgenic induction of the ETS-related gene (ERG) expression. However, the biological functions of ERG overexpression in CaP remain to be understood. ERG knockdown in TMPRSS2-ERG expressing prostate cancer ce...

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Dades bibliogràfiques
Publicat a:	Oncogene
Autors principals:	Sun, C, Dobi, A, Mohamed, A, Li, H, Thangapazham, R, Furusato, B, Shaheduzzaman, S, Tan, S-H, Vaidyanathan, G, Whitman, E, Hawksworth, DJ, Chen, Y, Nau, M, Patel, V, Vahey, M, Gutkind, JS, Sreenath, T, Petrovics, G, Sesterhenn, I A, McLeod, DG, Srivastava, S
Format:	Artigo
Idioma:	Inglês
Publicat:	2008
Matèries:	Article
Accés en línia:	https://ncbi.nlm.nih.gov/pmc/articles/PMC7556723/ https://ncbi.nlm.nih.gov/pubmed/18542058 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2008.183
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TMPRSS2-ERG Fusion, a Common Genomic Alteration in Prostate Cancer Activates C-MYC and Abrogates Prostate Epithelial Differentiation

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