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Structural basis for selectivity in a highly reducing type II polyketide synthase
In type II polyketide synthases (PKSs), the ketosynthase-chain length factor (KS-CLF) complex catalyzes polyketide chain elongation with the acyl carrier protein (ACP). Highly reducing type II PKSs, represented by IgaPKS, produce polyene structures instead of the well-known aromatic skeletons. Here,...
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| Publié dans: | Nat Chem Biol |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7556716/ https://ncbi.nlm.nih.gov/pubmed/32367018 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-020-0530-0 |
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