Structural Basis for Cyclization Specificity of Two Azotobacter Type III Polyketide Synthases: A SINGLE AMINO ACID SUBSTITUTION REVERSES THEIR CYCLIZATION SPECIFICITY

Type III polyketide synthases (PKSs) show diverse cyclization specificity. We previously characterized two Azotobacter type III PKSs (ArsB and ArsC) with different cyclization specificity. ArsB and ArsC, which share a high sequence identity (71%), produce alkylresorcinols and alkylpyrones through al...

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Detalhes bibliográficos
Main Authors: Satou, Ryutaro, Miyanaga, Akimasa, Ozawa, Hiroki, Funa, Nobutaka, Katsuyama, Yohei, Miyazono, Ken-ichi, Tanokura, Masaru, Ohnishi, Yasuo, Horinouchi, Sueharu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837156/
https://ncbi.nlm.nih.gov/pubmed/24100027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.487272
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