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Alteration of reaction and substrate specificity of a bacterial type III polyketide synthase by site-directed mutagenesis.

RppA, which belongs to the type III polyketide synthase family, catalyses the synthesis of 1,3,6,8-tetrahydroxynaphthalene (THN), which is the key intermediate of melanin biosynthesis in the bacterium Streptomyces griseus. The reaction of THN synthesis catalysed by RppA is unique in the type III pol...

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Detalhes bibliográficos
Main Authors: Funa, Nobutaka, Ohnishi, Yasuo, Ebizuka, Yutaka, Horinouchi, Sueharu
Formato: Artigo
Idioma:Inglês
Publicado em: 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1222926/
https://ncbi.nlm.nih.gov/pubmed/12139488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20020953
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