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Structural and Biochemical Elucidation of Mechanism for Decarboxylative Condensation of β-Keto Acid by Curcumin Synthase

The typical reaction catalyzed by type III polyketide synthases (PKSs) is a decarboxylative condensation between acyl-CoA (starter substrate) and malonyl-CoA (extender substrate). In contrast, curcumin synthase 1 (CURS1), which catalyzes curcumin synthesis by condensing feruloyl-CoA with a diketide-...

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Detalhes bibliográficos
Main Authors: Katsuyama, Yohei, Miyazono, Ken-ichi, Tanokura, Masaru, Ohnishi, Yasuo, Horinouchi, Sueharu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057783/
https://ncbi.nlm.nih.gov/pubmed/21148316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.196279
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