SETDB1 mediated histone H3 lysine 9 methylation suppresses MLL-fusion target expression and leukemic transformation

Epigenetic regulators play a critical role in normal and malignant hematopoiesis. Deregulation, including epigenetic deregulation, of the HOXA gene cluster drives transformation of about 50% of acute myeloid leukemia (AML). We recently showed that the histone 3 lysine 9 methyltransferase SETDB1 nega...

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Bibliographic Details
Published in:Haematologica
Main Authors: Ropa, James, Saha, Nirmalya, Hu, Hsiangyu, Peterson, Luke F., Talpaz, Moshe, Muntean, Andrew G.
Format: Artigo
Language:Inglês
Published: Fondazione Ferrata Storti 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7556517/
https://ncbi.nlm.nih.gov/pubmed/33054052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2019.223883
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