PAF1 complex interactions with SETDB1 mediate promoter H3K9 methylation and transcriptional repression of Hoxa9 and Meis1 in acute myeloid leukemia

The Polymerase Associated Factor 1 complex (PAF1c) is an epigenetic co-modifying complex that directly contacts RNA polymerase II (RNAPII) and several epigenetic regulating proteins. Mutations, overexpression and loss of expression of subunits of the PAF1c are observed in various forms of cancer sug...

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Udgivet i:Oncotarget
Main Authors: Ropa, James, Saha, Nirmalya, Chen, Zhiling, Serio, Justin, Chen, Wei, Mellacheruvu, Dattatreya, Zhao, Lili, Basrur, Venkatesha, Nesvizhskii, Alexey I., Muntean, Andrew G.
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2018
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5955148/
https://ncbi.nlm.nih.gov/pubmed/29774127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25204
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