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Mycolactone induces cell death by SETD1B-dependent degradation of glutathione

Mycobacterium ulcerans is a human pathogen that causes a necrotizing skin disease known as Buruli ulcer. Necrosis of infected skin is driven by bacterial production of mycolactone, a diffusible exotoxin targeting the host translocon (Sec61). By blocking Sec61, mycolactone prevents the transport of n...

詳細記述

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書誌詳細
出版年:PLoS Negl Trop Dis
主要な著者: Förster, Birgit, Demangel, Caroline, Thye, Thorsten
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7556509/
https://ncbi.nlm.nih.gov/pubmed/33006969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0008709
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