XPO1 regulates erythroid differentiation and is a new target for the treatment of β-thalassemia

β-thalassemia major (β-TM) is an inherited hemoglobinopathy caused by a quantitative defect in the synthesis of β-globin chains of hemoglobin, leading to the accumulation of free a-globin chains that aggregate and cause ineffective erythropoiesis. We have previously demonstrated that terminal erythr...

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Vydáno v:Haematologica
Hlavní autoři: Guillem, Flavia, Dussiot, Michaël, Colin, Elia, Suriyun, Thunwarat, Arlet, Jean Benoit, Goudin, Nicolas, Marcion, Guillaume, Seigneuric, Renaud, Causse, Sebastien, Gonin, Patrick, Gastou, Marc, Deloger, Marc, Rossignol, Julien, Lamarque, Mathilde, Choucair, Zakia Belaid, Gautier, Emilie Fleur, Ducamp, Sarah, Vandekerckhove, Julie, Moura, Ivan C., Maciel, Thiago Trovati, Garrido, Carmen, An, Xiuli, Mayeux, Patrick, Mohandas, Narla, Courtois, Geneviève, Hermine, Olivier
Médium: Artigo
Jazyk:Inglês
Vydáno: Fondazione Ferrata Storti 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7556489/
https://ncbi.nlm.nih.gov/pubmed/33054049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.210054
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