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CD11c+ T-bet+ B cells require IL-21 and IFN-γ from T(FH1) cells, and intrinsic Bcl-6 expression, but develop normally in the absence of T-bet
CD11c+ T-bet+ B cells generated during ehrlichial infection require CD4+ T cell help and IL-21 signaling for their development, but the exact T cell subset required had not been known. Here we show, in a mouse model of Ehrlichia muris, that T(FH1) cells provide help to CD11c+ T-bet+ B cells via the...
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| Publicat a: | J Immunol |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7556359/ https://ncbi.nlm.nih.gov/pubmed/32680956 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.2000206 |
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