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CD11c+ T-bet+ B cells require IL-21 and IFN-γ from T(FH1) cells, and intrinsic Bcl-6 expression, but develop normally in the absence of T-bet

CD11c+ T-bet+ B cells generated during ehrlichial infection require CD4+ T cell help and IL-21 signaling for their development, but the exact T cell subset required had not been known. Here we show, in a mouse model of Ehrlichia muris, that T(FH1) cells provide help to CD11c+ T-bet+ B cells via the...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Levack, Russell C., Newell, Krista L., Popescu, Maria, Cabrera-Martinez, Berenice, Winslow, Gary M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7556359/
https://ncbi.nlm.nih.gov/pubmed/32680956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.2000206
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