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Discovery of Novel Hsp90 C-Terminal Inhibitors Using 3D-Pharmacophores Derived from Molecular Dynamics Simulations

Hsp90 C-terminal domain (CTD) inhibitors are promising novel agents for cancer treatment, as they do not induce the heat shock response associated with Hsp90 N-terminal inhibitors. One challenge associated with CTD inhibitors is the lack of a co-crystallized complex, requiring the use of predicted a...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Tomašič, Tihomir, Durcik, Martina, Keegan, Bradley M., Skledar, Darja Gramec, Zajec, Živa, Blagg, Brian S. J., Bryant, Sharon D.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7555175/
https://ncbi.nlm.nih.gov/pubmed/32962253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21186898
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