Blocking ADAM17 Function with a Monoclonal Antibody Improves Sepsis Survival in a Murine Model of Polymicrobial Sepsis

Sepsis is the culmination of hyperinflammation and immune suppression in response to severe infection. Neutrophils are critical early responders to bacterial infection but can become highly dysfunctional during sepsis and other inflammatory disorders. The transmembrane protease ADAM17 (a disintegrin...

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Detalles Bibliográficos
Publicado en:Int J Mol Sci
Main Authors: Mishra, Hemant K., Ma, Jing, Mendez, Daniel, Hullsiek, Robert, Pore, Nabendu, Walcheck, Bruce
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2020
Assuntos:
Communication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7555020/
https://ncbi.nlm.nih.gov/pubmed/32932701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21186688
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