Loss of ULK1 Attenuates Cholesterogenic Gene Expression in Mammalian Hepatic Cells

The hepatic mevalonate (MVA) pathway, responsible for cholesterol biosynthesis, is a therapeutically important metabolic pathway in clinical medicine. Using an unbiased transcriptomics approach, we uncover a novel role of Unc-51 like autophagy activating kinase 1 (ULK1) in regulating the expression...

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Bibliographic Details
Published in:Front Cell Dev Biol
Main Authors: Rajak, Sangam, Iannucci, Liliana F., Zhou, Jin, Anjum, B., George, Nelson, Singh, Brijesh K., Ghosh, Sujoy, Yen, Paul M., Sinha, Rohit A.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Cell and Developmental Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7554540/
https://ncbi.nlm.nih.gov/pubmed/33083385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.523550
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