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Gfi1 upregulates c-Myc expression and promotes c-Myc-driven cell proliferation

Gfi1 is a zinc-finger transcriptional repressor that plays an important role in hematopoiesis. When aberrantly activated, Gfi1 may function as a weak oncoprotein in the lymphoid system, but collaborates strongly with c-Myc in lymphomagenesis. The mechanism by which Gfi1 collaborates with c-Myc in ly...

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Pubblicato in:Sci Rep
Autori principali: Zhang, Yangyang, Dong, Fan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7554040/
https://ncbi.nlm.nih.gov/pubmed/33051558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-74278-4
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