Inactivation of Ezh2 upregulates Gfi1 and drives aggressive Myc-driven Group 3 medulloblastoma

The most aggressive of four medulloblastoma (MB) subgroups are cMyc-driven Group 3 (G3) tumors, some of which overexpress EZH2, the histone H3K27 mono-, di- and trimethylase of polycomb repressive complex 2. Ezh2 has a context dependent role in different cancers as an oncogene or tumor suppressor an...

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Publicado no:Cell Rep
Main Authors: Vo, BaoHan T., Li, Chunliang, Morgan, Marc A., Theurillat, Ilan, Finkelstein, David, Wright, Shaela, Hyle, Judith, Smith, Stephanie M. C., Fan, Yiping, Wang, Yong-Dong, Wu, Gang, Orr, Brent A., Northcott, Paul A., Shilatifard, Ali, Sherr, Charles J., Roussel, Martine F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5415387/
https://ncbi.nlm.nih.gov/pubmed/28329683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.02.073
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