Spirodiketopiperazine-based CCR5 antagonists: Improvement of their pharmacokinetic profiles

Spirodiketopiperazine-based CCR5 antagonists, showing improved pharmacokinetic profiles without reduction in antagonist activity, were designed and synthesized. We also demonstrate the anti-HIV activity of a representative compound 12, as measured in a p24 assay.

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Pubblicato in:Bioorg Med Chem Lett
Autori principali: Nishizawa, Rena, Nishiyama, Toshihiko, Hisaichi, Katsuya, Hirai, Keisuke, Habashita, Hiromu, Takaoka, Yoshikazu, Tada, Hideaki, Sagawa, Kenji, Shibayama, Shiro, Maeda, Kenji, Mitsuya, Hiroaki, Nakai, Hisao, Fukushima, Daikichi, Toda, Masaaki
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7553643/
https://ncbi.nlm.nih.gov/pubmed/20005712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.11.018
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