D614G mutation alters SARS-CoV-2 spike conformational dynamics and protease cleavage susceptibility at the S1/S2 junction

The SARS-CoV-2 spike (S) protein is the target of vaccine design efforts to end the COVID-19 pandemic. Despite a low mutation rate, isolates with the D614G substitution in the S protein appeared early during the pandemic, and are now the dominant form worldwide. Here, we analyze the D614G mutation i...

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Udgivet i:bioRxiv
Main Authors: Gobeil, Sophie, Janowska, Katarzyna, McDowell, Shana, Mansouri, Katayoun, Parks, Robert, Manne, Kartik, Stalls, Victoria, Kopp, Megan, Henderson, Rory, Edwards, Robert J, Haynes, Barton F, Acharya, Priyamvada
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7553176/
https://ncbi.nlm.nih.gov/pubmed/33052347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.10.11.335299
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