Patients with gastrointestinal irritability after TGN1412-induced cytokine storm displayed selective expansion of gut-homing αβ and γδT cells

Following infusion of the anti-CD28 superagonist monoclonal antibody TGN1412, three of six previously healthy, young male recipients developed gastrointestinal irritability associated with increased expression of ‘gut-homing’ integrin β7 on peripheral blood αβT cells. This subset of patients with in...

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Vydáno v:Cancer Immunol Immunother
Hlavní autoři: McCarthy, Neil E., Stagg, Andrew J., Price, Claire L., Mann, Elizabeth R., Gellatly, Nichola L., Al-Hassi, Hafid O., Knight, Stella C., Panoskaltsis, Nicki
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Berlin Heidelberg 2020
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7552579/
https://ncbi.nlm.nih.gov/pubmed/33048222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-020-02723-4
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