Pathogenic mutations reveal a role of RECQ4 in mitochondrial RNA:DNA hybrid formation and resolution

The synthesis of mitochondrial DNA (mtDNA) is a complex process that involves the formation and resolution of unusual nucleic acid structures, such as RNA:DNA hybrids. However, little is known about the enzymes that regulate these processes. RECQ4 is a DNA replication factor important for mtDNA main...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Chang, Chou-Wei, Xu, Xiaohua, Li, Min, Xin, Di, Ding, Lin, Wang, Ya-Ting, Liu, Yilun
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7552406/
https://ncbi.nlm.nih.gov/pubmed/33046774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-74095-9
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