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Crystal structure of an RNA·DNA hybrid reveals intermolecular intercalation: Dimer formation by base-pair swapping

An intermolecular intercalation of base pairs was found at the CA step in the I222 crystal structure of the RNA·DNA hybrid, r(CAAAGAAAAG)·d(CTTTTCTTTG), which contains two-thirds of the polypurine tract sequence of HIV-1 with a substitution of cytosine for the initial adenine. This sequence crystall...

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Detalhes bibliográficos
Main Authors: Han, Gye Won, Kopka, Mary L., Langs, David, Sawaya, Michael R., Dickerson, Richard E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC170898/
https://ncbi.nlm.nih.gov/pubmed/12872000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1533326100
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