Crystal structure of caspase-11 CARD provides insights into caspase-11 activation

Murine caspase-11 is the centerpiece of the non-canonical inflammasome pathway that can respond to intracellular LPS and induce pyroptosis. Caspase-11 contains two components, an N-terminal caspase recruitment domain (CARD) and a C-terminal catalytic domain. The aggregation of caspase-11 is thought...

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Detalhes bibliográficos
Publicado no:Cell Discov
Main Authors: Liu, Muziying, Zhou, Kang, Xu, Zhihao, Ma, Huan, Cao, Xiaocong, Yin, Xueying, Zeng, Weihong, Zahid, Ayesha, Fu, Sicheng, Ni, Kang, Ye, Xiaodong, Zhou, Ying, Bai, Li, Zhou, Rongbin, Jin, Tengchuan
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Singapore 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7552397/
https://ncbi.nlm.nih.gov/pubmed/33083005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41421-020-00201-w
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