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The autoinhibited state of MKK4: Phosphorylation, putative dimerization and R134W mutant studied by molecular dynamics simulations
Protein kinases are crucial components of the cell-signalling machinery that orchestrate and convey messages to their downstream targets. Most often, kinases are activated upon a phosphorylation to their activation loop, which will shift the kinase into the active conformation. The Dual specificity...
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| Publicat a: | Comput Struct Biotechnol J |
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| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Research Network of Computational and Structural Biotechnology
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7550801/ https://ncbi.nlm.nih.gov/pubmed/33101607 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2020.09.017 |
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