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KRAS(G12C)–AMG 510 interaction dynamics revealed by all-atom molecular dynamics simulations
The first KRAS(G12C) targeting inhibitor in clinical development, AMG 510, has shown promising antitumor activity in clinical trials. On the molecular level, however, the interaction dynamics of this covalently bound drug–protein complex has been undetermined. Here, we disclose the interaction dynam...
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| Foilsithe in: | Sci Rep |
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| Príomhúdar: | |
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
Nature Publishing Group UK
2020
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7371895/ https://ncbi.nlm.nih.gov/pubmed/32686745 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-68950-y |
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