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The conserved AAA-ATPase PCH-2 (TRIP13) regulates spindle checkpoint strength

Spindle checkpoint strength is dictated by the number of unattached kinetochores, cell volume, and cell fate. We show that the conserved AAA-ATPase PCH-2/TRIP13, which remodels the checkpoint effector Mad2 from an active conformation to an inactive one, controls checkpoint strength in Caenorhabditis...

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Detalhes bibliográficos
Publicado no:Mol Biol Cell
Main Authors: Défachelles, Lénaïg, Russo, Anna E., Nelson, Christian R., Bhalla, Needhi
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7550697/
https://ncbi.nlm.nih.gov/pubmed/32697629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E20-05-0310
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