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TRIP13(PCH-2) promotes Mad2 localization to unattached kinetochores in the spindle checkpoint response
The spindle checkpoint acts during cell division to prevent aneuploidy, a hallmark of cancer. During checkpoint activation, Mad1 recruits Mad2 to kinetochores to generate a signal that delays anaphase onset. Yet, whether additional factors contribute to Mad2’s kinetochore localization remains unclea...
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| Udgivet i: | J Cell Biol |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Rockefeller University Press
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4639874/ https://ncbi.nlm.nih.gov/pubmed/26527744 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201505114 |
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