An SCN1B Variant Affects Both Cardiac-Type (Na(V)1.5) and Brain-Type (Na(V)1.1) Sodium Currents and Contributes to Complex Concomitant Brain and Cardiac Disorders

Voltage-gated sodium (Na(V)) channels are transmembrane proteins that initiate and propagate neuronal and cardiac action potentials. Na(V) channel β subunits have been widely studied due to their modulatory role. Mice null for Scn1b, which encodes Na(V) β1 and β1b subunits, have defects in neuronal...

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Bibliographische Detailangaben
Veröffentlicht in:Front Cell Dev Biol
Hauptverfasser: Martinez-Moreno, Rebecca, Selga, Elisabet, Riuró, Helena, Carreras, David, Parnes, Mered, Srinivasan, Chandra, Wangler, Michael F., Pérez, Guillermo J., Scornik, Fabiana S., Brugada, Ramon
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020
Schlagworte:
Cell and Developmental Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7550680/
https://ncbi.nlm.nih.gov/pubmed/33134290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.528742
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