An SCN1B Variant Affects Both Cardiac-Type (NaV1.5) and Brain-Type (NaV1.1) Sodium Currents and Contributes to Complex Concomitant Brain and Cardiac Disorders

Voltage-gated sodium (NaV) channels are transmembrane proteins that initiate and propagate neuronal and cardiac action potentials. NaV channel β subunits have been widely studied due to their modulatory role. Mice null for Scn1b, which encodes NaV β1 and β1b subunits, have defects in neuronal develo...

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Main Authors: Rebecca Martinez-Moreno, Elisabet Selga, Helena Riuró, David Carreras, Mered Parnes, Chandra Srinivasan, Michael F. Wangler, Guillermo J. Pérez, Fabiana S. Scornik, Ramon Brugada
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020-09-01
Colecção:Frontiers in Cell and Developmental Biology
Assuntos:
NaV1.5
NaV1.1
NaVβ1
NaVβ1b
cardiac arrhythmia
brain hyperexcitability
Acesso em linha:https://www.frontiersin.org/article/10.3389/fcell.2020.528742/full
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