High-throughput mutagenesis reveals unique structural features of human ADAR1

Adenosine Deaminases that act on RNA (ADARs) are enzymes that catalyze adenosine to inosine conversion in dsRNA, a common form of RNA editing. Mutations in the human ADAR1 gene are known to cause disease and recent studies have identified ADAR1 as a potential therapeutic target for a subset of cance...

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Publicat a:Nat Commun
Autors principals: Park, SeHee, Doherty, Erin E., Xie, Yixuan, Padyana, Anil K., Fang, Fang, Zhang, Yue, Karki, Agya, Lebrilla, Carlito B., Siegel, Justin B., Beal, Peter A.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7550611/
https://ncbi.nlm.nih.gov/pubmed/33046702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18862-2
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