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Replacement of TCR Dβ With Immunoglobulin D(H) DSP2.3 Imposes a Tyrosine-Enriched TCR Repertoire and Adversely Affects T Cell Development

Enrichment for tyrosine in immunoglobulin CDR-H3 is due in large part to natural selection of germline immunoglobulin D(H) sequence. We have previously shown that when D(H) sequence is modified to reduce the contribution of tyrosine codons, epitope recognition is altered and B cell development, anti...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Levinson, Michael, Khass, Mohamed, Burrows, Peter D., Schroeder, Harry W.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7550431/
https://ncbi.nlm.nih.gov/pubmed/33133088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.573413
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