Preimmune Control of the Variance of TCR CDR-B3: Insights Gained From Germline Replacement of a TCR Dβ Gene Segment With an Ig D(H) Gene Segment

We have previously shown that the sequence of the immunoglobulin diversity gene segment (D(H)) helps dictate the structure and composition of complementarity determining region 3 of the immunoglobulin heavy chain (CDR-H3). In order to test the role of germline D sequence on the diversity of the prei...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Khass, Mohamed, Levinson, Michael, Schelonka, Robert L., Kapoor, Pratibha, Burrows, Peter D., Schroeder, Harry W.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7518465/
https://ncbi.nlm.nih.gov/pubmed/33042119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.02079
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