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Replacement of TCR Dβ With Immunoglobulin D(H) DSP2.3 Imposes a Tyrosine-Enriched TCR Repertoire and Adversely Affects T Cell Development
Enrichment for tyrosine in immunoglobulin CDR-H3 is due in large part to natural selection of germline immunoglobulin D(H) sequence. We have previously shown that when D(H) sequence is modified to reduce the contribution of tyrosine codons, epitope recognition is altered and B cell development, anti...
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| Vydáno v: | Front Immunol |
|---|---|
| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Frontiers Media S.A.
2020
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7550431/ https://ncbi.nlm.nih.gov/pubmed/33133088 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.573413 |
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