IL-17A contributes to lung fibrosis in a model of chronic pulmonary graft-versus-host disease

BACKGROUND: Chronic pulmonary graft-versus-host disease (cpGVHD) after hematopoietic cell transplant (HCT) manifests as progressive airway and parenchymal lung fibrosis. Based on our prior data, mice that undergo allogeneic HCT with Tbet-knockout donors (AlloTbet(−/−)) have increased lung Th17 cells...

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Bibliografiske detaljer
Udgivet i:Transplantation
Main Authors: Martinu, Tereza, McManigle, William C, Kelly, Francine L, Nelson, Margaret E, Sun, Jesse, Zhang, Helen L, Kolls, Jay K, Gowdy, Kymberly M, Palmer, Scott M
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7550218/
https://ncbi.nlm.nih.gov/pubmed/31658231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TP.0000000000002837
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