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Lipid Deprivation Induces a Stable, Naive-to-Primed Intermediate State of Pluripotency in Human PSCs

Current challenges in capturing naive human pluripotent stem cells (hPSCs) suggest that the factors regulating human naive versus primed pluripotency remain incompletely defined. Here we demonstrate that the widely used Essential 8 minimal medium (E8) captures hPSCs at a naive-to-primed intermediate...

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Bibliografiske detaljer
Udgivet i:Cell Stem Cell
Main Authors: Cornacchia, Daniela, Zhang, Chao, Zimmer, Bastian, Chung, Sun Young, Fan, Yujie, Soliman, Mohamed A., Tchieu, Jason, Chambers, Stuart M., Shah, Hardik, Paull, Daniel, Konrad, Csaba, Vincendeau, Michelle, Noggle, Scott A., Manfredi, Giovanni, Finley, Lydia W.S., Cross, Justin R., Betel, Doron, Studer, Lorenz
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7549840/
https://ncbi.nlm.nih.gov/pubmed/31155483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2019.05.001
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