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Lipid Deprivation Induces a Stable, Naive-to-Primed Intermediate State of Pluripotency in Human PSCs

Current challenges in capturing naive human pluripotent stem cells (hPSCs) suggest that the factors regulating human naive versus primed pluripotency remain incompletely defined. Here we demonstrate that the widely used Essential 8 minimal medium (E8) captures hPSCs at a naive-to-primed intermediate...

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Detalhes bibliográficos
Publicado no:Cell Stem Cell
Main Authors: Cornacchia, Daniela, Zhang, Chao, Zimmer, Bastian, Chung, Sun Young, Fan, Yujie, Soliman, Mohamed A., Tchieu, Jason, Chambers, Stuart M., Shah, Hardik, Paull, Daniel, Konrad, Csaba, Vincendeau, Michelle, Noggle, Scott A., Manfredi, Giovanni, Finley, Lydia W.S., Cross, Justin R., Betel, Doron, Studer, Lorenz
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7549840/
https://ncbi.nlm.nih.gov/pubmed/31155483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2019.05.001
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