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Development and characterization of protein kinase B/AKT isoform-specific nanobodies

The serine/threonine protein kinase AKT is frequently over-activated in cancer and is associated with poor prognosis. As a central node in the PI3K/AKT/mTOR pathway, which regulates various processes considered to be hallmarks of cancer, this kinase has become a prime target for cancer therapy. Howe...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Merckaert, Tijs, Zwaenepoel, Olivier, Gevaert, Kris, Gettemans, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7549812/
https://ncbi.nlm.nih.gov/pubmed/33045011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0240554
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